Uric acid, hyperuricemia and ischemic stroke
10.3760/cma.j.issn.1673-4165.2014.05.008
- VernacularTitle:尿酸、高尿酸血症与缺血性卒中
- Author:
Yuping YAN
;
Guizhi WU
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Uric Acid;
Hyperuricemia
- From:
International Journal of Cerebrovascular Diseases
2014;22(5):392-396
- CountryChina
- Language:Chinese
-
Abstract:
Uric acid is an end product of purine metabolism.Hyperuricemia is defined as serum uric acid level ＞420 μmol/L in man,and 360 μmol/L in woman.Several mechanisms can cause elevated serum uric acid levels.Systematic reviews and Meta-analyses have shown that hyperuricemia is significantly correlated with the increased morbidity and mortality in patients with ischemic stroke.However,as a powerful antioxidant and a radical scavenger,uric acid seems to have a neuroprotective effect in ischemic stroke.Uric acid administered early can enhance the effect of recombinant tissue plasminogen activator (rtPA) thrombolytic therapy in rats with thromboembolic stroke.Therefore,it is necessary to conduct a randomized controlled trial for the clinical effects of rtPA thrombolysis in combination with uric acid in patients with acute ischemic stroke.A phase 3 clinical trial is ongoing,and its results are worth waiting for.
