Correlation of ApoE gene polymorphism and serum uric acid in Ningxia Hui Autonomous Region
10.3760/cma.j.issn.1009-9158.2014.06.009
- VernacularTitle:宁夏人群载脂蛋白E基因多态性与血清尿酸水平的相关性研究
- Author:
Jie WU
;
Ling QIU
;
Xinqi CHENG
;
Qing WANG
;
Lan NI
;
Xiuzhi GUO
;
Qian CHENG
;
Jianhua HAN
;
Tao XU
;
Guangjin ZHU
- Publication Type:Journal Article
- Keywords:
Apolipoproteins E;
Polymorphism,genetic;
Uric acid;
Lipid metabolism
- From:
Chinese Journal of Laboratory Medicine
2014;(6):434-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toexplore the correlation of ApoE gene polymorphism and serum uric acid levels in Ningxia Hui Autonomous Region , China.Methods A case-control study.October 2011 to November 2011, five hundred twenty eight ( 296 male, 232 female ) apparently healthy individuals were studied.Questionnaires and physical examinations were performed by standard operation procedure.Fasting blood was collected for biochemistry testing including serum lipid parameters , uric acid concentration and creatinine levels.The multi-ARMS PCR was applied to determine ApoE genotypes ,and the relation of ApoE genotypes with serum lipid parameters and uric acid levels were analyzed.Non-normal distribution were compared using cause and inspection.Results The common six kinds of ApoE genotype can be detected.The total cholesterol ( TC) ,low density lipoprotein cholesterol ( LDL-C) and uric acid ( UA) levels in different genotype subgroups had statistical differences.The individuals with ε2/3 genotype had a significantly greater reductions in TC and LDL-C levels but increment in uric acid concentration than those withε3/3 and ε3/4 genotype (P<0.05).The effect of ApoE gene polymorphism on uric acid levels still remained significantly after adjustment for age , gender , region and other factors.Conclusion The ApoE polymorphism is associated with serum uric acid levels and individuals with ε2 allele have higher serum uric acid levels.
