Role of phosphorylation of p53 at Ser392 in cancer therapy
10.3969/j.issn.0529-1356.2014.03.026
- VernacularTitle:p53-Ser392的磷酸化在肿瘤治疗中的作用
- Author:
Jingli LIU
;
Xinli SHI
;
Cheng CUI
;
Laifeng REN
;
Wenguang ZHENG
;
Mingyuan LI
- Publication Type:Journal Article
- Keywords:
p53;
Ser392;
Phosphorylation;
Cancer therapy;
Gene mutant;
Western blotting
- From:
Acta Anatomica Sinica
2014;(3):437-440
- CountryChina
- Language:Chinese
-
Abstract:
Phosphorylation is the most common way of p 53 post-translational modifications .However , gaps still exist in our knowledge regarding the role and mechanism of phosphorylation of p 53 at Ser392 in carcinogenesis and cancer prevention.In the present study, we summarized the effect of phos-p53-Ser392 to wild-type and mutant p53, the regulation by DNA damage agents and protein kinase , and the significance of phosphorylation of p 53-Ser392 in cancer treatment .
