The expression and clinical value of CD40 ligand(CD154) and CD4+CD25+FoxP3+ regulatory T cells in patients with ankylosing spondylitis
10.3760/cma.j.issn.1008-6706.2014.13.009
- VernacularTitle:CD154与CD4+CD25+FoxP3+调节性T细胞在强直性脊柱炎患者外周血中的表达及意义
- Author:
Xiujuan LI
;
Shengqi HUANG
;
Ani WANG
;
Shiying LI
;
Weiguang CHEN
;
Feng WEI
- Publication Type:Journal Article
- Keywords:
CD40 ligand;
T-lymphocytes,regulatory;
Spondylitis,ankylosing
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(13):1942-1944
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels and clinical value of the peripheral blood CD154 and CD4+CD25+FoxP3+ regulatory T cells in patients with ankylosing spondylitis (AS).Methods 20 patients with AS and 20 healthy donors were studied.Flow cytometry was used to analyze the levels of the peripheral blood CD154,CD4+CD25+FoxP3+ regulatory T cells and HLA-B27.And T-test,Spearman correlation analysis were used in statistical analysis.Results The level of the peripheral blood CD154 was significantly higher in AS patients than that in normal controls [(4.38 ± 1.64) ％ vs.(1.92 ± 1.13) ％ (t =5.836,P ＜ 0.05)],and the level of the peripheral blood CD4+CD25+FoxP3+ regulatory T cells was lower in AS patients than that in normal controls [(3.87 ± 1.11) ％ vs.(6.30 ± 1.46) ％ (t =6.254,P ＜ 0.05)].There was negative correlation between the peripheral blood CD154 and CD4+CD25+FoxP3+ regulatory T cells in AS (r =-0.539,P ＜ 0.05).No relationship of the peripheral blood CD154,CD4+CD25+FoxP3+ regulatory T cells with laboratory parameters were found in AS.Conclusion The levels of the peripheral blood CD154 and CD4+CD225+FoxP3+ regulatory T cells in AS are abnormal,and may be involved in the immunological pathogenesis of AS.
