Genetic polymorphism analysis of CYP2C19 in Uighur and Han nationality patients with coronary heart ;disease
10.3969/j.issn.1008-0074.2014.02.04
- VernacularTitle:维吾尔族、汉族冠心病人群CYP2C19基因多态性分析
- Author:
Reyihan YIMING
;
Palida ABULAITI
;
Gulizhaer MAIMAITIMING
- Publication Type:Journal Article
- Keywords:
Cytochrome P-450 enzyme system;
Polymorphism,single nucleotide;
Coronary artery disease
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the genotype and allele distribution feature of cytochrome P450 2C19 (CYP2C19) in Uighur and Han nationality patients With coronary heart disease (CHD).Methods:A total of 355 CHD patients Without kinship,including 194 Uighur cases and 161 Han cases,Were selected. CYP2C19 genetic polymorphism Was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP),it’ s compared betWeen different age groups (<60 years and≥60 years)of the tWo nationalities.Results:Compared With Han na-tionality patients,there Were significant increase in allele*1 frequency [(64.9% vs.75.2%),P<0.01],signifi-cant decrease in allele*2 (29.5% vs.22.2%),and allele*3 (5.6% vs.2.6%) frequencies (P<0.05 all);geno-type*1/*1 significant increase [(38.5% vs. 57.7%),P<0.01],*1/*2 significant decrease [(44.7% vs. 31.5%),P<0.05],and other four genotype betWeen tWo nationalities Were no significant difference (P>0.05);fast metabolic patter frequency (38.5% vs. 57.7%)significant increase,moderate metabolic patter frequency (52.8% vs. 31.5%)significant decrease (P<0.01 all)in Uighur nationality patients ;In a same nationality,age had no significant impact on its genotype and allele distribution (P>0.05 all).Conclusion:There are significant differences in cytochrome P450 2C19 genotype and allele distribution betWeen Uighur nationality and Han nationali-ty CHD patients,Understanding those is of important significance to guide clinical medication and improve patients' prognosis.
