Effect of Nicorandil on unstable angina patients with persistent weak positive for troponin-I
10.3969/j.issn.1008-0074.2014.02.24
- VernacularTitle:尼可地尔在持续性肌钙蛋白I弱阳性心绞痛患者中的作用
- Author:
Yuanzhou ZHU
;
Liangzi HU
;
Sijia LU
;
Xiongbing DU
;
Chao CHANG
;
Li TIAN
;
Yibai FENG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Troponin;
Nicorandil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(2):197-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss effect of nicorandil on unstable angina patients With persistent Weakly positive for troponin I (TnI).Methods:A total of 111 unstable angina patients With persistent Weakly positive for TnI Were randomly divided into control group (received routine treatment,55 cases) and intervention group (received nic-orandil 5mg,3 times/d based on routine treatment,56 cases).The relief of chest pain in one Week,the recurrent hospitalization for chest pain aggravation in 3 months and the cardiac mortality rate in one year betWeen tWo groups Were observed in tWo groups. Results:Compared With control group,the relief of angina pectoris in one Week (63.6% vs. 91.1%,χ2=11.97,P=0.0005)significantly increased,re-hospitalization for chest pain aggravation in three months (56.4% vs.19.6%,χ2=15.91,P=0.0001)significantly decreased in intervention group;but cardiac mortality rate during one year betWeen tWo groups Was no significant difference (5.5% vs. 8.9%,χ2=0.50,P=0.4792).Conclusion:Nicorandil can significantly reduce the unstable angina and re-hospitalization for chest pain aggravation in patients With persistent Weakly positive for TnI,but there Was no significant difference in reducing mortality Within one year betWeen tWo groups.
