Acquired resistance to anti-EGFR antibodies in metastatic colorectal cancer
10.3760/cma.j.issn.1673-422X.2014.05.012
- VernacularTitle:转移性结直肠癌抗EGFR单抗获得性耐药的研究进展
- Author:
Minmin LI
;
Xiang BI
;
Zhehai WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Receptor,epidermal growth factor;
Antibodies,monoclonal;
Drug resistance
- From:
Journal of International Oncology
2014;41(5):357-360
- CountryChina
- Language:Chinese
-
Abstract:
The combination of chemotherapy with anti-epidermal growth factor receptor antibodies such as cetuximab and panitumumab which prolong the survival time in the past few years have been widely adopted for the treatment of metastatic colorectal cancer.However,a large number of patients develop resistance to these agents,while there is no standard treatment after acquired resistance yet.Therefore,finding out the mechanisms of acquired drug resistance and putting forward reasonable methods to overcome the acquired resistance will be improve its curative effect.
