Vitamin E Potentiates the Anti-nociceptive Effects by Intraperitoneal Administration of Lidocaine in Rats.
10.11620/IJOB.2016.41.4.191
- Author:
Hye Jin KIM
1
;
Hae Ji YANG
;
Sun Hyong KIM
;
Dan A KIM
;
Seong Ju KIM
;
Han na PARK
;
Jin Sook JU
;
Dong Kuk AHN
Author Information
1. Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea. dkahn@knu.ac.kr
- Publication Type:Original Article
- Keywords:
lidocaine;
vitamin E;
formalin;
pain;
trigeminal
- MeSH:
Administration, Intravenous;
Animals;
Facial Pain;
Formaldehyde;
Humans;
Injections, Intraperitoneal;
Injections, Subcutaneous;
Lidocaine*;
Male;
Naloxone;
Rats*;
Rats, Sprague-Dawley;
Receptors, Opioid;
Vitamin E*;
Vitamins*
- From:International Journal of Oral Biology
2016;41(4):191-197
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present study was to evaluate effects of vitamin E on intravenous administration of lidocaine-induced antinociception. Experiments were carried out using male Sprague-Dawley rats. Orofacial formalin-induced nociceptive behavioral responses were used as the orofacial animal pain model. Subcutaneous injection of formalin produced significant nociceptive scratching behavior. Intraperitoneal injection of 5 and 10 mg/kg of lidocaine attenuated formalin-induced nociceptive behavior in the 2nd phase, compared to the vehicle-treated group. Intraperitoneal injection of 1 g/kg of vitamin E also attenuated the formalin-induced nociceptive behavior in the 2nd phase, compared to the vehicle-treated group. However, low dose of vitamin E (0.5 g/kg) did not affect the nociceptive behavioral responses produced by subcutaneous injection of formalin. The present study also investigated effects of intraperitoneal injection of both vitamin E and lidocaine on orofacial formalin-induced behavioral responses. Vehicle treatment affected neither formalin-induced behavioral responses nor lidocaine-induced antinociceptive effects. However, intraperitoneal injection of 0.5 g/kg of vitamin E enhanced the lidocaine-induced antinociceptive effects in the 2nd phase compared to the vehicle-treated group. Intraperitoneal injection of naloxone, an opioid receptor antagonist, did not affect antinociception produced by intraperitoneal injections of both vitamin E and lidocaine. These results suggest that treatment with vitamin E enhances the systemic treatment with lidocaine-induced antinociception and reduces side effects when systemically treated with lidocaine. Therefore, the combined treatment with vitamin E and lidocaine is a potential therapeutic for chronic orofacial pain.
