Change in serum level of 8-hydroxy-deoxyguanosine during corticosteroid treatment in patients with active Graves' ophthalmopathy
10.3760/cma.j.issn.1000-6699.2014.03.011
- VernacularTitle:Graves眼病活动期患者糖皮质激素治疗前后血清8-羟基脱氧鸟嘌呤水平临床对照研究
- Author:
Xiaozhen YE
;
Jun LIU
;
Yangtian WANG
;
Minjuan ZHANG
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
Oxidative DNA damage;
8-hydroxy-deoxyguanosine;
Graves' ophthalmopathy;
Corticosteroid
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(3):218-220
- CountryChina
- Language:Chinese
-
Abstract:
The change in serum level of 8-hydroxy-deoxyguanosine (8-OHdG),an oxidative stress biomarker,in patients with active Graves' ophthalmopathy (GO) during corticosteroid treatment was observed.The serum level of 8-OHdG was significantly increased in patients with active GO as compared with that of normal controls and patients with Graves' disease (P ＜ 0.05).After systemic corticosteroid treatment,patients with GO showed significantly lowered 8-OHdG level as compared with that before treatment and patients with Graves' disease.These changes in serum 8-OHdG level were accompanied by decreases in clinical activity score (P ＜ 0.05) during corticosteroid treatment.Oxidative stress may play a role in the pathogenesis of GO.Serum 8-OHdG level may be used as an objective and quantitative parameter in patients with GO during immunosuppressive treatment.
