Biomechanical and histological analysis of alveolar distraction osteogenesis in a canine model
10.3969/j.issn.2095-4344.2014.20.018
- VernacularTitle:犬牙槽骨牵张成骨的生物力学和组织学分析
- Author:
Miao ZHOU
;
Yuejuan CHE
;
Mingyan GUO
;
Daiying HUANG
;
Zhengguo PIAO
;
Xiaowei YU
;
Songling CHEN
- Publication Type:Journal Article
- Keywords:
osteogenesis,distraction;
mechanics;
histology;
dental implantation
- From:
Chinese Journal of Tissue Engineering Research
2014;(20):3212-3217
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Alveolar distraction osteogenesis is an important method for treating alveolar bone atrophy, the osteogenesis process and biomechanics play a crucial role in the fol owing implantation and repair. At present, no related experimental studies are found.
OBJECTIVE:To analyze the biomechanical and histological characteristics of alveolar distraction osteogenesis in a canine model.
METHODS:Twelve adult mongrel canines received premolars extraction and alveoloplasty in mandible to establish an atrophy alveolar model. After 3 months, a segmental alveolar osteotomy was performed in the randomly selected unilateral atrophy alveolar and two intra-osseous distractors were placed. After a 7-days latency period, the alveolar ridge was augmented at a rate of 1.0 mm/d for 5 days. After a consolidation of 1, 2, and 3 months, the canines were sacrificed and the specimens of the distracted alveolar bone were harvested for clinical, radiographic, histological and biomechanical analysis.
RESULTS AND CONCLUSION:The alveolar distractors obtained good healing with surrounding tissue. The atrophy alveolar bones were augmented for (4.80±0.50) mm and (5.12±0.47) mm by clinical and radiographic findings immediately after distraction, respectively. The bone trabeculae in the distracted chamber matured from 1 to 3 months of consolidation by histological analysis. The shearing force of alveolar distraction chamber increased from 1 to 3 months. After 3 months’ consolidation, the shearing force of distracted chamber was comparable to host bone. The histological and biomechanical property of distracted alveolar chamber is comparable to host bone after 3 months’ consolidation.
