Study on the relationship between E-selectin and proliferative diabetic retinopathy
10.3760/cma.j.issn.1008-1372.2014.02.013
- VernacularTitle:增殖型糖尿病视网膜病变与血清 E-选择素的相关性
- Author:
Zhihong ZHANG
;
Haifang ZHANG
;
Jiangxin CAO
;
Shiyue YIN
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy/blood;
E-selectin/blood;
Hemoglobin A,glycosylated/blood;
Prognosis
- From:
Journal of Chinese Physician
2014;(2):189-191
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between proliferative diabetic retinopathy and E-selectin level .Meth-ods Ninty-two patients with diabetic retinopathy were divided into two groups based on the results of fundus fluorescence angiography :basic diabetic retinopathy (BDR) group, and proliferative diabetic retinopathy (PDR) group.Body mass index (BMI), fasting blood-glucose (FPG), total cholesterol (TC), triglycerides (TG), hemoglobin A1c (HbA1c), systolic blood pressure (SBP), diastolic blood pressure ( DBP) , and E-selectin levels of two groups were determined and compared .Results Compared with normal control group, the BDR and PDR group soluble E-selectin (sE-sel), FPG, HbA1c levels were increased significantly ( P <0.05).There was no significant difference in the SBP, DBP, BMI, TC, and TG levels in BDR group compared with control group ( P >0.05).The level of E-sel was positively correlated with HbA 1c and FBG in diabetic retinopathy patients .Conclusions High levels of sE-sel, HbA1c, and FPG were the important risk factors for diabetic retinopathy , and were closely related to the severity of PDR .Detection of serum sE-sel and HbA1c will help to predict the severity and prognosis of diabetic retinopathy .
