Expression of HERG1 and Kv3.4 in oral lichen planus

VernacularTitle:口腔扁平苔藓组织中 HERG1和 Kv3．4钾离子通道蛋白的表达
Author: Kehong MIAO ; Minhai NIE ; Chengcheng SONG ; Pingping SONG ; Baoqin WU
Publication Type:Journal Article
Keywords: Oral lichen planus; HERG1; Kv3.4; Potassium channel
From: Journal of Practical Stomatology 2014;(2):206-210
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression of HERG1 and Kv3.4 in normal oral mucosa(NOM)and oral lichen planus (OLP).Methods:20 OLP and 1 6 NOM specimens were collected and immunohistochemically stained(IHC)by SP method for the detection of HERG1 and Kv3.4 protein expression.Results:HERG1 and Kv3.4 were negative or weak-positive in the sapmles of bas-al layer of NOMand non-erosive OLP,but positive in basal layer,spinous layer and granular layer of erosive OLP.The expression of HERG1 and Kv3.4 was higher in OLP than in NOM tissues (P <0.05);and higher in erosive OLP than in non-erosive OLP(P <0.05).In OLP HERG1 expression was positively related to Kv3.4(P <0.05).Conclusion:HERG1 and Kv3.4 may be related to the development of OLP.