Changes in expression of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in pathological scar tissue of rabbit ears after scar-skin replantation
10.3760/cma.j.issn.1671-0290.2014.01.017
- VernacularTitle:兔耳病理性瘢痕皮回植术后组织中基质金属蛋白酶-1及金属蛋白酶组织抑制剂-1表达的变化
- Author:
Xuelian ZHAO
;
Xiaoguang SU
;
Chui ZHANG
;
Chunli ZHANG
;
Zhuonan ZHANG
;
Baoheng ZHENG
- Publication Type:Journal Article
- Keywords:
Hypertrophic scar;
Scar skin replantation;
Pathological scar;
Matrix metalloproteinase-1 (MMP-1);
Tissue inhibitor of metalloproteinase-1 (TIMP-1)
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2014;20(1):62-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of MMP-1 and TIMP-1 expression in the pathological scar tissue after scar-skin replantation and to explore the mechanism of treating pathological scars with scar-skin replantation through a rabbit ear model.Methods Rabbit ears were used to establish the hypertrophic scar animal model in this study.Specimens were taken for three times:normal skin,hypertrophic scar and scar-skin replantion separately.We then performed HE staining,Masson staining and immunohistochemical staining to observe the expression of MMP-1 and TIMP-1 in these three groups of specimens.Results The expression of both MMP-1 and TIMP-1 significantly increased in the hypertrophic scar tissue after scar-skin replantation compared with the control group (P＜0.01).The expression of MMP-1 increased more significantly than that of TIMP-1 (P＜0.01).Conclusions The mechanism of scar-skin replantation's effect in the treatment for hypertrophic scar is relevant to the imbalance in the interaction between MMP-1 and TIMP-1 in the scar tissue.
