The relationship between T lymphocyte subsets and hepatitis B reactivation after chemotherapy
10.3760/cma.j.issn.1008-6706.2014.02.005
- VernacularTitle:化疗后T细胞亚群变化与乙型肝炎病毒再激活关系研究
- Author:
Jianqi ZHUANG
;
Xiaohui ZHENG
;
Xiaodan ZHENG
;
Keqing HUANG
- Publication Type:Journal Article
- Keywords:
Chemotherapy;
T lymphocyte subsets;
Hepatitis B virus;
Reactivation
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(2):170-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes ofT lymphocyte subsets CD3+,CD4+,CD8+ in hepatitis B reactivation after chemotherapy.Methods Flow cytometry was used to detect T lymphocyte subsets of 32 patients with hepatitis B reactivation before and after chemotherapy.In addition,25 patients without hepatitis B reactivition were chosen as control group.Results After chemotherapy,the percentage of CD3+ and CD4+ T lymphocytes and the ratio of CD4+/CDs+ were significantly reduced than those before chemotherapy (P ＜ 0.05).However,the percentage of CD8+ T lymphocytes was not significantly changed(P ＞ 0.05).Conclusion The chemotherapy can change the number and ratio of T lymphocyte subsets,the inhibition of the cellular immune function is one of the reason of hepatitis B virus reactivation.
