Meta-analysis on diagnostic value of monoclonal gastric cancer 7 antigen for gastric cancer
10.3969/j.issn.1673-4130.2014.05.018
- VernacularTitle:胃癌相关抗原MG7-Ag对胃癌诊断价值的Meta分析
- Author:
Xianwu YUAN
;
Shiqin HE
;
Along LI
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
Meta-analysis;
sensitivity and specificity
- From:
International Journal of Laboratory Medicine
2014;(5):549-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical diagnostic value of monoclonal gastric cancer 7 antigen(MG7-Ag) in gastric cancer through a meta-analysis .Methods The PubMed ,Embase ,ISI Web of Knowledge ,China National Knowledge Infrastructure (CNKI) ,Wanfang databases were retrieved from their establishment to April 5 ,2013 .The qualities of the included literatures were assessed by the QUADAS scale .The heterogeneity test and meta-analysis were conducted by the Stata12 and the Meta-DiSc soft-wares .Results 610 articles were retrieved from databases .7 articles containing 4 516 cases conformed with the included standard . The sensitivity of MG7-Ag in diagnosing gastric cancer was 0 .72(95% CI:0 .68 -0 .76) ,its specificity was 0 .94(95% CI:0 .93 -0 .94) ,the positive likelihood ratio was 6 .09(95% CI:3 .36-11 .07) ,the negative likelihood ratio was 0 .34 (95% CI:0 .21-0 .56) and the AUC was 0 .893 4 .Conclusion The comprehensive research results indicate that MG7-Ag has the sensitivity of 0 .72 for di-agnosing gastric cancer ,which is higher than that of currently used diagnostic markers such as carcino-embryonic antigen(CEA) , CA50 and CA19-9 ,which has the high value for excluding other diseases and can be used as a marker for diagnosing gastric cancer .
