Expression of Gult-1 in cervical adenocarcinoma and its significance

VernacularTitle:葡萄糖转运蛋白1在子宫颈腺癌组织中的表达及其意义
Author: Haixia HU ; Wei LI ; Zhengwen XIONG ; Hongwei LI ; Hong SU ; Xiaodong NIU
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Gult-1; Prognosis
From: Cancer Research and Clinic 2014;26(1):39-41
CountryChina
Language:Chinese
Abstract: Objective To study the expression of Gult-1 in cervical adenocarcinoma and prognosis analysis.Methods Gult-1 was detected by immunohistochemistry (EnVision) in cervical adenocarcinoma and cancer adjacent tissue.Results In cancer adjacent tissue and cervical adenocarcinoma,the positive rates of Gult-1 were 2.22 ％ (1/45),58.67 ％ (44/75),respectively,and there was statistical significance between them (x2 =38.23,P =0.00).The expression of Gult-1 was not correlated to age,histological classification and infiltrated depth (all P ＞ 0.05).However,it was correlated to tumor size,histological grade and lymphatic nodes metastasis (all P ＜ 0.05).The survival rate of positive Gult-1 patients was lower than negative Gult-1 patients (x 2 =4.27,P =0.04).Conclusion The over-expression of Guh-1 in cervical adenocarcinoma indicates poorly differentiated cancer,the possibility of lymphatic nodes metastasis and unfavourable prognosis.