Clinical significance of BRCA1 and Ki-67 expression in breast cancer
10.3760/cma.j.issn.1006-9801.2014.01.001
- VernacularTitle:乳腺癌组织中乳腺癌易感基因1、增殖细胞核抗原Ki-67表达的临床意义
- Author:
Jingjing WU
;
Xi CHEN
;
Xiong CHEN
;
Xuenong OUYANG
;
Xiaolong WU
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
BRCA1;
Ki-67;
Immunohistochemistry
- From:
Cancer Research and Clinic
2014;26(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathologic features and prognostic significance of BRCA1 and Ki-67 expression in breast cancer.Methods The expression levels of BRCA1 and Ki-67 were assayed by immunohistochemistry in 194 cases of breast cancer tissues.The correlations of BRCA1 and Ki-67 expression with patients' clinicopathologic features were also analysed.Results Low expression of BRCA1 was detected in the lymph node metastasis group,ER/PR negative group,and HER-2 positive group in 194 patients with breast cancer (P ＜ 0.05),as well as in the triple negative breast cancer (TNBC) group compared to non-TNBC group (P ＜0.05).High expression of Ki-67 was detected in patients with higher histological grade,negative ER/PR,and positive HER-2 (P ＜ 0.05).Furthermore,negative correlation was found between the expression of BRCA1 and Ki-67 (P ＜ 0.05).The combination of low expression of BRCAl and high expression of Ki-67 was mostly found in the patients with postmenopausal,lower histological grade,lymph node metastasis,negative ER/PR and positive HER-2 (P ＜ 0.05).However,there was no significant difference between TNBC and non-TNBC.Conclusion Joint detection of BRCA1 and Ki-67 might play an important role in predicting clinical outcomes of breast cancer,especially BRCA1 may be one of prognostic factors in TNBC.
