The significance of genetic expression of IGF-Ⅰ , ERK, and GLUT4 in adipose tissue of patients with metabolic syndrome and colorectal cancer and its significance
10.3760/cma.j.issn.1000-6699.2013.10.013
- VernacularTitle:代谢综合征合并结直肠癌患者脂肪组织IGF-Ⅰ、ERK、GLUT4mRNA表达水平的变化及临床意义
- Author:
Yan FENG
;
Cui LIN
;
Shihua ZHAO
;
Wei WANG
;
Yangang WANG
;
Fenglian WANG
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Colorectal cancer;
Insulin-like growth factor-Ⅰ;
Extracellular signal regulated kinase;
Glucose transporter 4
- From:
Chinese Journal of Endocrinology and Metabolism
2013;29(10):876-878
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] To explore the mRNA expression of insulin-like growth factor-Ⅰ (IGF-Ⅰ),extracellular signal regulated kinase (ERK),and glucose transporter 4 (GLUT4) in greater omental adipose tissue of patients with metabolic syndrome and colorectal cancer.The mRNA expression of IGF-Ⅰ,ERK,and GLUT4 in greater omental adipose tissue of the subjects was measured by RT-PCR.(1) The mRNA expression level of IGF-Ⅰ and ERK in the metabolic syndrome group was significantly higher than that in the control group (P＜0.01),while in colorectal cancer subgroup the expression was significantly higher than that in the non-colorectal cancer subgroup (P＜ 0.01).The expression of GLUT4 was obviously lowered (P＜0.01).(2) The expression of ERK was positively correlated with that of IGF-Ⅰ (r =0.608,P＜0.01).The fasting insulin was positively correlated with the expression of ERK and IGF-Ⅰ(r =0.538,0.439,P ＜ 0.01),and negatively with that of GLUT4 (r =-0.457,P ＜ 0.01).There may be relationship between ERK plus IGF-Ⅰ and metabolic syndrome complicated with colorectal cancer.The lowered GLUT4 expression may be related to insulin resistance in metabolic syndrome.
