Pulmonary protective effect of mucosolvan treatment in elderly lung cancer patients undergoing radioactive seed implantation
10.3760/cma.j.issn.0254-9026.2013.11.003
- VernacularTitle:沐舒坦在老年肺癌患者放射性粒子植入术中肺的保护作用
- Author:
Jingkui YANG
;
Xiaodong HUO
;
Weiliang YAN
;
Guangjun ZHENG
;
Zheng FENG
;
Jinshuang LV
- Publication Type:Journal Article
- Keywords:
Cancer,non-small-cell lung;
Inflammatory mediators
- From:
Chinese Journal of Geriatrics
2013;32(11):1145-1147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the pulmonary protective effect of large and small doses of mucosolvan in elderly patients with lung cancer undergoing radioactive seed implantation.Methods 93 patients with non-small cell lung cancer undergoing radioactive seed implantation guided by CT were selected and randomly divided into 3 groups:the high-dose group,the low-dose group and control group (n-31,each).All patients received the mucosolvan treatment with routine immunization and nutrition support after implantation.Patients was given mucosolvan 990 mg/d and 300 mg/d by continuous intravenous pumping in high-dose and small-dose groups respectively.Patients in the control group was given saline.The incidence of pneumothorax and plasma levels of C reactive protein (CRP),tumor necrosis factor alpha (TNF alpha),neutrophils (ANC) were compared between the three groups at 1 d,3 d and 5 d after implantation.Results There was no statistically significant difference in plasm levels of CRP,TNF alpha and ANC between the three groups at 1 d and 3 d after implantation (all P＞0.05).Plasma levels of CRP,TNF alpha and ANC were lower in highdose group than in low-dose group and control group at 5 d after implantation (F=3.596,3.555,3.406,respectively,all P＜0.05).The incidence of pneumothorax was lower in high dose group than in control group (x2 =4.31,P ＜ 0.05).Conclusions Perioperative application of high-dose mucosolvan can relieve lung inflammatory reaction rapidly and reduce the incidence of pneumothorax in elderly lung cancer patients undergoing radioactive seed implantation.
