Brain-derived neurotrophic factor and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2013.09.009
- VernacularTitle:脑源性神经营养因子与脑缺血
- Author:
Ying LI
;
Yonglu HUANG
;
Zongliang GAO
- Publication Type:Journal Article
- Keywords:
Brain Ischemia;
Brain-Derived Neurotrophic Factor;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2013;21(9):707-710
- CountryChina
- Language:Chinese
-
Abstract:
Brain-derived neurotrophic factor (BDNF) is one of the most prevalent growth factors in the central nervous system (CNS).In the development and maturation processes of the nervous system,BDNF plays an important role in maintaining neuronal function,promoting neuronal regeneration after injury,and preventing neuronal degeneration,etc.At present,many researchers are being dedicated to the research of BDNF for treatment of brain ischemia and have achieved some progress.This article reviews the molecular biological characteristics and biological function of BDNF,roles and mechanisms in cerebral ischemia,and the possibility as an intervention target of cerebral ischemia.
