Reasonable naloxone administration in cancer pain management
10.3969/j.issn.1000-8179.20131975
- VernacularTitle:纳洛酮在癌痛治疗中的合理应用
- Author:
Huilong LIU
;
Hongyi LI
;
Duanqi LIU
- Publication Type:Journal Article
- Keywords:
opioids;
naloxone;
cancer pain;
constipation
- From:
Chinese Journal of Clinical Oncology
2013;(24):1487-1491
- CountryChina
- Language:Chinese
-
Abstract:
Naloxone is a synthetic pan-opioid receptor competitive antagonist of the opioid receptors inside and outside the cen-tral nervous system. After systemic administration, it reverses almost all opioid effects. Systemically administered naloxone is used to reverse the life-threatening opioid toxicity. A number of studies have analyzed the importance of oral naloxone as a peripheral opioid an-tagonist in cancer patients. Naloxone has shown satisfactory efficacy for opioid-induced constipation (OIC). Ultra-low dose of naloxone has been reported to enhance the anti-nociceptive effect of morphine and reduce morphine consumption. We summarize the results from current studies of naloxone administration in cancer pain management.
