Mechanisms and reversal strategies of tumor multidrug resistance
10.3760/cma.j.issn.1673-422X.2013.12.003
- VernacularTitle:肿瘤多药耐药的产生机制及逆转策略
- Author:
Jing WU
;
Rui YANG
;
Shuye LIU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Drug resistance,multiple;
Nanotechnology
- From:
Journal of International Oncology
2013;40(12):889-892
- CountryChina
- Language:Chinese
-
Abstract:
Tumor multidrug resistance (MDR) is the leading cause of clinical chemotherapy failure and death.Researches show that the occurrence of MDR is related to P-glycoprotein,multidrug resistance-associated proteins,breast cancer resistance-associated proteins,lung resistance-related proteins and other factors.Now the reversal strategies of MDR include chemical drugs reversal,gene reversal,immune reversal,traditional Chinese medicine reversal and drug-loaded nano-system reversal,which make some progress and help to improve the effect of cancer chemotherapy.
