Influence of high body mass index on IVF-ET pregnancy outcome in patients with polycystic ovary syndrome *
10.3969/j.issn.1671-8348.2013.27.016
- VernacularTitle:高体质量指数对多囊卵巢综合征患者辅助生育妊娠结局的影响
- Author:
Hua LOU
;
Xingling WANG
;
Lijun SUN
;
Yichun GUAN
;
Yang GOU
;
Xuemei WANG
;
Weiwei LI
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
embryo transfer;
IVF-ET
- From:
Chongqing Medicine
2013;(27):3246-3248
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of high body mass index (BMI) on in vitro fertilization and embryo transfer (IVF-ET) pregnancy outcome in the patients with polycystic ovary syndrome (PCOS) .Methods A retrospective cohort study was conducted using existing data on 224 PCOS patients with IVF-ET by the standard long protocol in this hospital from Jan 2009 to Dec 2011 .All patients were divided into 2 groups according to BMI ,the high BMI group(BMI≥24 .0 ,64 cases) and the normal BMI group(18 .5≤BMI<24 .0 ,160 cases) .The differences of pregnaney outcomes between the high BMI and normal BMI PCOS pa-tients were compared .Results 1 .Basic testosterone(T) in the high BMI group was higher than that in the normal BMI group(P<0 .05) .2 .There were no statistical difference in the number of retrived oocytes ,dose of Gn ,Gn duration ,fertilization rate between the two groups(P>0 .05);the high BMI group demonstrated the higher endometrial thickness and lower good quality embryo rate than the normal BMI group(P<0 .05) .3 .There were no statistical difference in the clinical pregnancy rate and the abortion rate be-tween the two groups(P>0 .05) ,the high BMI group had the higher risk of developing gestational diabetes(GDM)than the normal BMI group(P<0 .05) .Conclusion PCOS patient with high BMI is liable to develop hyperandrogenism and increases the occurrence rate of pregnancy complication gestational diabetes mellitus (GDM ) ,but without affecting the clinical pregnancy rate .
