Pharmacoeconomic analysis of paclitaxel plus epirubicin or carboplatin for metastatic breast cancer
10.3969/j.issn.1000-8179.20130046
- VernacularTitle:两种方案治疗转移性乳腺癌的临床评价与药物经济学分析*
- Author:
Xingyu CHEN
;
Xiaorui WANG
;
Guolei DONG
;
Zhongsheng TONG
- Publication Type:Journal Article
- Keywords:
metastatic breast cancer;
paclitaxel;
carboplatin;
epirubicin;
cost-effectiveness analysis
- From:
Chinese Journal of Clinical Oncology
2013;(19):1160-1164
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study evaluated the economical effects of two different regimens for metastatic breast cancer, namely, paclitaxel plus either carboplatin (TP) or epirubicin (TE). Methods:The cost-effectiveness method in pharmacoeconomics was adopted to analyze retrospectively the two different regimens. Results:The median follow up was 23.5 (range:9 to 42) months. The overall response rate for TP and TE were 78.33%and 80.00%, respectively. The 1-and 2-year progression-free survival rates of TP and TE were 43.6%and 38.9%and 10.8%and 17.4%, respectively. The 1-and 2-year overall survival rates were 80.3%and 78.3%, respectively for TP, whereas the corresponding values for TE were 53.2%and 47.9%. No statistically significant difference was found between the two groups (P>0.05). Cost-effectiveness analysis showed that the average costs of the TP and TE regimens were 10 303.8 and 13 853.3 yuan, respectively, with corresponding cost-effectiveness ratios of 131.54 and 173.17 (P<0.01). For the chemotherapy toxicity, the alopecia reactions of the TP group were significantly lower than those of the TE group (P<0.01). Conclusion:The short-and long-term efficacies of the two regimens were similar. TP regimen was the optimal scheme for advanced metastatic breast cancer.
