Effects on dimethylformamide liver function and oxidative stress of low level arsenic on mouse liver and serum *
10.3969/j.issn.1671-8348.2013.23.022
- VernacularTitle:低砷染毒致小鼠肝功能及氧化损伤的实验研究
- Author:
Bochao WANG
- Publication Type:Journal Article
- Keywords:
arsenic;
oxidative stress;
liver function
- From:
Chongqing Medicine
2013;(23):2758-2759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects on dimethylformamide liver function and oxidative stress of low level arsenic on mouse liver and serum .Methods 40 health KM mouses were randomly divided into 0 ,12 .5 ,25 .0 ,50 .0μg/L arsenic and exposured 10 weeks .The ALT ,AST ,MDA ,SOD ,GSH-Px in serum and liver were determined .Results In serum :the AST was significantly increase in 50 .0 μg/L dose(P<0 .05);GSH-Px were significant increase in 12 .5 μg/L dose(P<0 .05) .In the liver :the albumin was significantly increase in middle dose(P<0 .05) .Conclusion Low arsenic can induce liver damage on mice ,but can increase an-tioxidatant GSH-Px in arsenic group .
