Clinical analysis of 3 patients who were diagnosed ankylosing spondylitis concurrent with multiple myeloma

VernacularTitle:强直性脊柱炎合并多发性骨髓瘤三例报道及文献复习
Author: Yuehong HUO ; Qian WANG ; Yan ZHAO ; Liping MENG ; Liping SUN
Publication Type:Journal Article
Keywords: Spondylitis,ankylosing; Multiple myeloma; Diagnosis
From: Chinese Journal of Rheumatology 2013;17(9):627-630
CountryChina
Language:Chinese
Abstract: Objective To investigate the pathogenesis and clinical features of ankylosing spondylitis (AS) concurrent with multiple myeloma (MM).Methods The clinical characteristics,pathogenesis,diagnosis and treatment of 3 cases who were diagnosed as AS concurrent with MM were analyzed and relevant literatures were reviewed.Results MM was confirmed in patients who had long-term stable AS.A wide variety of manifestations,including persistent pain in spine and thorax,pathologic fracture,anemia,kidney damage and nervous system abnormalities were frequently presented.These patients were insensitive to nonsteroidal anti-inflammatory drug treatment,and they had a unfavorable prognosis.Conclusion Patients who are diagnosed as AS concurrent with MM can present with a variety of clinical features.Manifestations which are difficult to explain clinically by AS and poor response to treatment especially when the patients have longterm stable AS are potential clues for MM.