The expression and significance of multidrug resistance gene in children with refractory epilepsy

VernacularTitle:难治性癫(癎)患儿多药耐药基因的表达及意义
Author: Baodong PANG ; Yan DONG ; Runchun ZHANG ; Yin LIU ; Shuping LIU ; Lihua CAO ; Jiahua WU
Publication Type:Journal Article
Keywords: refractory epilepsy; multidrug resistance gene; fluorescence quantitative PCR; children
From: Journal of Clinical Pediatrics 2009;(11):1023-1025
CountryChina
Language:Chinese
Abstract: Objective To study the expression and significance of multidrug resistance gene (MDR1) in children with refractory epilepsy (RE). Methods Children with RE (n = 30), non-RE (n = 30) and healthy children (n=30) were collected. The expression of MDR1-mRNA in peripheral blood was analyzed by fluorescence quantitative PCR. The relationship of MDRI-mRNA with epileptic frequency and numbers of antiepileptic drugs (AEDs) were observed. Results The expression of MDR1 in RE group obviously increased when compared with that of non-RE group and healthy group (P < 0.01, P < 0.01) ; MDR1 expression was more among patients with high frequent epilepsy than patients with low frequent epilepsy (P < 0.01) ; more in patients administered with four kinds of AEDs than those with two or three kinds of AEDs (P < 0.01). Concinsions MDR1 overexpression in blood of children with RE may be linked to drug-resistant mechanism of RE. It might be used as a clinical indicator of RE.