Expression and clinical significance of △Np63a in human esophageal squamous cell carcinoma

VernacularTitle:△Np63α在食管鳞癌中的表达及其临床意义
Author: Bailing LI ; Qing XUE ; Guanxin ZHANG ; Chong WANG ; Zhiyun XU
Publication Type:Journal Article
Keywords: △Np63 α; Esoplageal neoplasms; Neoplasm metastasis; Prognosis; Neoplasms,squamous cell
From: Chinese Journal of Thoracic and Cardiovascular Surgery 2013;(2):102-104
CountryChina
Language:Chinese
Abstract: Objective The aim of this study was to assess the value of △Np63α in predicting tumor recurrence after curative resection in esophageal squamous cell carcinoma (ESCC) patients.Methods We analyzed △Np63α protein cxpression in 304 clinicopathologically characterized ESCC cases by immunohistochemistry.Results We found △Np63α expression was positive in 122 (40％) of 304 cases.△Np63α expression was higher in the cancer tissue than in non-tumorous control tissue at protein level(P =0.034).There was a significant difference of △Np63α expression in patients categorized according to invasive depth (P =0.001),tumor position (P =0.001) and lymph nodes metastasis condition (P =0.001).Multivariate analyses showed that △Np63α was an independent prognostic marker for ESCC recurrence.Conclusion △Np63α is associated with outcome of ESCC and can be a novel predictor for poor prognosis of ESCC patients after curative resection.