Relationship between the expression of SOCS-1/3 in the peripheral blood mononuclear cells and interferon therapeutic response in patients with chronic hepatitis B
10.3760/cma.j.issn.1008-6706.2013.13.001
- VernacularTitle:慢性乙型肝炎患者外周血细胞因子信号转导抑制因子-1、3表达与干扰素α疗效的关系
- Author:
Wenli LI
;
Maosheng WU
;
Xiling LIU
;
Jifen ZHU
;
Ruirong XU
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Chronic;
Interferon-alpha;
Mechanotransduction;
cellular
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(13):1921-1923
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the the expression of SOCS-1/3 in the peripheral blood mononuclear cells (PBMCs) and interferon therapeutic response in patients with chronic hepatitis B.Methods 50 patients with chronic hepatitis B were given interferon therapy.After 24 weeks treatment,according to biochemical and virologic response,they were divided into two groups:response and non response group.HBV-DNA was detected by PCR.The SOCS-1/3 mRNA levels were measured by RT-PCR.Results The expression of SOCS-1 in the PBMCs of response group after 24 weeks treatment was significantly higher than that before interferon therapy (P ＜ 0.05).The expression of SOCS-3 in the PBMCs of response group after 24 weeks trentment was significantly lower than that before interferon therapy (P ＜ 0.05).In non response group,there were no significant differences in the expression of SOCS-1/3 (P ＞ 0.05).Conclusion The increase expression of SOCS-1 mRNA and the decrease of SOCS-3 mRNA in the PBMCs in chronic hepatitis B patients received 24 weeks interferon-therapy probably is relevant to the IFN-α antiviral effect.
