Expression of nm23-H1 and heat shock protein 27 and their significance in non-small cell lung carcinoma
10.3760/cma.j.issn.1006-9801.2013.04.001
- VernacularTitle:nm23-H1及热休克蛋白27在非小细胞肺癌中的表达及临床意义
- Author:
Xingyang XUE
;
Jian ZHAO
;
Ming ZHOU
;
Guangri ZHAO
;
Wenfan FU
;
Ronghao YANG
;
Jiang MENG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Immunohistochemistry;
nm23-H1;
Heat shock protein 27
- From:
Cancer Research and Clinic
2013;(4):217-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of nm23-H1 and heat shock protein 27 (HSP27) and their clinical significance on development and metastasis in non-small cell lung carcinoma (NSCLC).Methods 75 tumor tissues from patients with NSCLC were included as experimental group and 28 pulmonary benign lesion tissues were as control group.The expressions of nm23-H1 and HSP27 in patients with different clinical and pathological characters were detected by immunohistochemistry.Results nm23-H1 and HSP27 were mainly expressed in cytoplasm,the positive rates of nm23-H1 and HSP27 were significantly higher in the experimental group than that in control group [41.3 ％ (31/75) vs 7.1％ (2/28),x2 =10.946,P =0.001,80.0 ％ (60/75) vs 46.4 ％ (13/28),x2 =11.131,P =0.001].Compared with control group,the positive rate of HSP27 was correlated with the degree of tumor differentiation (x2 =4.191,P =0.041).nm23-H1 was related with HSP27 in lung cancer (r =0.284,P =0.013).Conclusion nm23-H1 and HSP27 are related to the occurrence and development of NSCLC.The joint detection of nm23-H1 and HSP27 should be helpful to the diagnosis and judge the biological behavior of NSCLC.
