The relationship between the expression of EGFR NF-κB and radiosensitivity in human nasopharyngeal carcinoma
10.3969/j.issn.1001-1781.2009.15.003
- VernacularTitle:EGFR及NF-κB与鼻咽癌放射敏感性的相关性研究
- Author:
Chunni YANG
;
Yibing YANG
;
Yiqin AI
- Publication Type:Journal Article
- Keywords:
nasopharyngeal carcinoma;
epidermal growth factor receptor;
nuclear factor-kappa B;
radiosensitivity
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(15):678-681
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the expression of EGFR and NF-ΚB and the relationship between the two fac-tors and radiosensitivity in human nasopharyngeal carcinoma. Methods The expression of EGFR and NF-ΚB were detected with immunohistochemical staining SP methods in forty-one patients. The radiotherapy effect was assessed by follow up visit and clinical judgement. All of the forty-one patients were divided into three groups: the complete response group,the partial response(or the stable disease)group and the progressive disease group. Result:The ex-pression of EGFR and NF-ΚB were detected in human nasophaTyngeal carcinoma tissues, which were not in normal ones. EGFR and NF-ΚB were significant difference of the radiosensitivity in nasopharyngeal carcinoma tissues (P< 0. 05). The expression of EGFR and NF-ΚB in the complete response-group and the partial response(or the stable disease)-group were lower than the progressive disease-group(P<0. 05),and there was no significant difference between the complete response-group and the partial response(or the stable disease)-group(P>0. 05). The two factors'expression had negative correlation with radiosensitivity. Conclusion: EGFR and NF-ΚB, as important tar-gets, could predict the radiosensitivity of NPC, which could be helpful for targeting treatment and promote the effect of radiotherapy of NPC.
