Cardiac/coronary artery lesion in Kawasaki disease treated with different kind of intravenous immunoglobulin therapy in Shanghai from 1998-2008
10.3969/j.issn.1000-3606.2009.10.001
- VernacularTitle:川崎病丙种球蛋白治疗策略与心脏损害及冠状动脉病变的相关性研究(1998-2008上海地区调查报告
- Author:
Lijian XIE
;
Cenyan YU
;
Xiaojin MA
;
Shubao CHEN
;
Rongfa WANG
;
Meirong HUANG
;
Zhongzhen GUO
;
Jinjin JIANG
;
Xiaoxun ZHOU
;
Qing YU
;
Dingzhong QIU
;
Yonghao GUI
;
Shoubao NING
;
Min HUANG
;
Guoying HUANG
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
intravenous immunoglobulin;
coronary artery lesion
- From:
Journal of Clinical Pediatrics
2009;(10):901-905
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of different kind of intravenous immunoglobulin (IVIG) therapy in treating Kawasaki disease (KD) and preventing cardiac consequences (coronary artery lesion, CAL). Methods A questionnaire form and guideline for KD diagnosis were sent to 50 hospitals providing pediatric medical care in Shanghai. The data from a total of 1 682 KD patients were collected. It included 1 064 males and 618 females from 1998 through 2008 in Shanghai. The average age of the KD patients was (2.57±2.33) years old (0.1-18.8 years).The patients had been divided into 6 groups for different IVIG therapy, which included 1 g/kg once, 2 g/kg once, 0.4-0.5 g/kg five times, 1 g/kg twice, 2 g/kg twice and others. SAS 6.12 software was used for statistical analysis. Results In all KD patients, the patients treated with IV1G in 5th-10th day of illness has the least cardiac complication and CAL incidence and the group with IVIG therapy of 1 g/kg twice also has the least cardiac complication and CAL incidence. Conclusions The best doses of IVIG in treating KD is 1 g/kg twice and the IVIG therapy should be used in 5th-10th day of KD illness.
