Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium.
10.3346/jkms.2000.15.1.88
- Author:
Young Ho LEE
1
;
Seong Jae CHOI
;
Aeree KIM
;
Chul Hwan KIM
;
Jong Dae JI
;
Gwan Gyu SONG
Author Information
1. Department of Internal Medicine and Anatomical Pathology, College of Medicine, Korea University, Seoul.
- Publication Type:Original Article
- Keywords:
Arthritis, Rheumatoid;
Prostaglandin-Endoperoxide Synthase;
Synovial Membrane
- MeSH:
Adult;
Aged;
Arthritis, Rheumatoid/pathology;
Arthritis, Rheumatoid/enzymology*;
Cell Division;
Female;
Fibrin/metabolism;
Human;
Isoenzymes/metabolism;
Isoenzymes/biosynthesis*;
Male;
Middle Age;
Neutrophil Infiltration;
Osteoarthritis/enzymology;
Prostaglandin-Endoperoxide Synthase/metabolism;
Prostaglandin-Endoperoxide Synthase/biosynthesis*;
Stromal Cells/pathology;
Stromal Cells/enzymology;
Synovial Membrane/pathology;
Synovial Membrane/enzymology*
- From:Journal of Korean Medical Science
2000;15(1):88-92
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to investigate the expression and localization of cyclooxygenase-1 and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA). Synovial tissues from 9 patients with RA and 5 patients with osteoarthritis (OA) were examined for COX-1 and COX-2 expressions by immunohistochemical staining using 2 polydonal COX-1 and COX-2 antibodies. In RA synovia, synovial lining cells showed intense immunostaining for COX-1, whereas slight to moderate staining was observed in inflammatory cells, stromal fibroblast-like cells and vascular endothelial cells. There was no significant difference in COX-1 expression between RA and OA synovia. The localization of COX-2 expression dearly differed from that of COX-1 expression, being most intense in inflammatory cells. However, there was no difference in COX-1 and COX-2 expressions between RA and OA synovial tissues. Our observations support that inflammatory mechanisms modulated by COX-1 and COX-2 in chronic RA synovium might be similar to those in chronic OA synovium.
