STUDY ON CELL MEDIAED-IMMUNITY INDUCED BY PORIN OF SALMONELLA TYPHIMURIUM

VernacularTitle:鼠伤寒沙门氏菌porin诱导BALB／c小鼠细胞免疫的研究
Author: Yuewu ZHAO ; Fenglan ZHAO ; Jun HU ; Youmei XU
Publication Type:Journal Article
Keywords: Salmonella typhimurium; Porin; Delayed-type hypersensitivity IL- 2; T cell transfer immuity
From: Chinese Journal of Zoonoses 2000;(6):45-47
CountryChina
Language:Chinese
Abstract: AimTo investigate cell mediated-immunity induced by porin of Salmonella typhimurium(STM). Methods Level of delayed-type hypersensitivity(DTH), IL-2 of immunized BALB/c mice were determined by footpad swelling,MTT and transfered protective rate of T cells purified by neloy wool were studied with 500LD50 of the bacteria(intraperitoneally). Results A marked level of DTH(3. 6±0. 2,P＜0. 01),IL-2(26.2±4.9,P＜0. 01) and the immuinized T cells transfer protec tive level (42.9％ ,P＜0. 01) was induced by porin from STM. Conclusion These results indicated that porin of STM might in duced stronger CMI in BALB/c mice.