Anti-inflammatory and Analgesic Effects of Combined Application of Glucosamine and Chondroitin Sulfate
- VernacularTitle:联合使用氨基葡聚糖和硫酸软骨素抗炎镇痛作用实验研究
- Author:
Chunyan YANG
;
Gang HAN
;
Jingcheng WANG
;
Haizhong YUAN
;
Yue DONG
;
Guanyu ZHAI
;
Ying FAN
;
Yin KANG
- Publication Type:Journal Article
- Keywords:
ghcosamine;
chondroitin sulfate;
anti-inflammatory;
analgesic
- From:
Chinese Journal of Sports Medicine
2010;(3):313-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-inflammatory and analgesic effects of combined application of glucosamine(GS)and chondroitin sulfate(CS).Methods The acute and chronic anti-inflammatory effects of combined application of GS and CS were observed respectively through carrageen-induced paw edema and cotton-induced inguinal granuloma of rats.The analgesic effect of combined application of GS and CS was investigated by the mouse pain model induced by 0.6% acetic acid Results As compared with the control group,the degree of paw edema and the weight of granuloma in combined application of GS and CS group were significantly reduced(P<0.05 and P<0.01,respectively);and the writhing number of mice decreased significantly(P<0.05).Conclusion Combined application of glucosamine and chondroitin sulfate demonstrates obviously anti-inflammatory and analgesic effects.
