Liposomes delivery system and liposomal oxaliplatin for the treatment of colorectal cancer
10.3760/cma.j.issn.1673-9752.2013.01.021
- VernacularTitle:脂质体递药系统与奥沙利铂脂质体对结直肠癌治疗的研究
- Author:
Chuang YANG
;
Zhongxue FU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Oxaliplatin;
Drug delivery system;
Liposomes
- From:
Chinese Journal of Digestive Surgery
2013;(1):78-80
- CountryChina
- Language:Chinese
-
Abstract:
Oxaliplatin is effective for the treatment of advanced colorectal cancer,but its application is restricted because of the dose-limiting toxicity.As drug carriers,liposomes are featured with delay release,lesion targeting and they could decrease the side effects of drugs.Active targeting modification of the liposome can change the biological distribution of the anticancer drugs,reduce or reverse multidrug resistance of tumor cells and enhance the effect of anti-tumor drugs.With these characteristics mentioned above,lipsomes containing oxaliplatin may play an important role in the treatment of colorectal cancer.
