Advances of PRDM genes and DNA methylation in cancer
10.3760/cma.j.issn.1673-422X.2013.03.004
- VernacularTitle:PRDM基因及DNA甲基化与肿瘤的关系
- Author:
Yongli TAN
;
Shuangxiang TAN
;
Ruicheng HU
- Publication Type:Journal Article
- Keywords:
DNA methylation;
Genes,tumor suppressor;
Neoplasms;
PRDM genes
- From:
Journal of International Oncology
2013;(3):174-177
- CountryChina
- Language:Chinese
-
Abstract:
PRDI-BFI and RIZ homology domain containing proteins (PRDM) play a key role in cell differentiation and proliferation.Most members of the PRDM gene family are tumor suppressor genes which involved in tumorigenesis and abnormal expression in a variety of tumors.Aberrant DNA methylation often silences these genes,which may occur in the early stage of tumor,Cancer can be reversed by demethylation,which provides a new way for cancer treatment.
