Interference mechanism of liposome PGE1 on survival of expanded flap

VernacularTitle:前列腺素E1影响扩张皮瓣存活的干预机制
Author: Weiwei LI ; Zhifei LIU ; Qun QIAO ; Xiaojun WANG ; Ru ZHAO ; Lin ZHU
Publication Type:Journal Article
Keywords: Prostaglandin E1 (PGE1); Expanded flap; Interference mechanism
From: Chinese Journal of Medical Aesthetics and Cosmetology 2013;(1):47-50
CountryChina
Language:Chinese
Abstract: Objective To investigate the mechanism of liposome PGE1 on the survival of the expanded flap.Methods The minipigs were set up as an animal model.They were divided into 2 groups.The expanded flaps (8 cm ×2 cm) were designed and elevated on the back of an minipig.An image analysis technology was used to evaluate the survival rate of the expanded flap,while realtimePCR technique was used to investigate the molecular mechanism.Results The survival area of the expanded flap in the Lipo PGE1 group was significantly enlarged (P＜0.01) compared with the control group.The VEGF,iNOS and Ang-1 gene expression decreased,but TGF-β1 gene expression increased.But there was no significant difference between two groups (P＞0.05).Conclusions The Lipo PGE1 could promote survival rate of the expanded flap,but the mechanism does not involve the regulation of VEGF,iNOS,Ang-1 and TGF-β1 gene expression.