A comparison of efficacy of dexmedetomidine and pethidine for prevention of postoperative shivering in patients requiring general anesthesia

VernacularTitle:右美托咪定与哌替啶预防全麻患者术后寒战效果的比较
Author: Sheliang SHEN ; Wenyuan WANG ; Shuangfei HU
Publication Type:Journal Article
Keywords: Dexmedetomidine; Meperidine; Anesthesia,general; Shivering; Postoperative complications
From: Chinese Journal of Anesthesiology 2012;(10):1211-1213
CountryChina
Language:Chinese
Abstract: Objective To compare the efficacy of dexmedetomidine and pethidine for prevention of postoperative shivering in patients requiring general anesthesia.Methods Sixty ASA Ⅰ-Ⅲ patients of both sexes,aged 18-75 yr,weighing 40-85 kg,were randomly divided into 2 groups (n =30 each) ∶ pethidine group (group P) and dexmedetomidine group (group D).At the end of pneumoperitoneum,pethidine 0.5 mg/kg and dexmedetomidine 1 μg/kg were infused intravenously over 10 min in groups P and D,respectively.The shivering,respiratory depression,somnolence,nausea and vomiting,bradycardia and hypotension were recorded within 1 h after operation.Results There were no significant differences in the incidence and degree of shivering between group D and group P (P ＞ 0.05).The incidences of respiratory depression and nausea and vomiting were significantly lower,and the incidence of bradycardia was significantly higher in group D than in group P(P ＜ 0.05).Conclusion The efficacy of dexmedetomidine for prevention of postoperative shivering is better than pethidine in patients requiring general anesthesia.