Expression of caspase-3 in colon carcinoma,colon adenoma and normal colon mucosa and its clinical significance
10.3760/cma.j.issn.1673-4904.2012.32.002
- VernacularTitle:caspase-3在正常结肠黏膜、结肠腺瘤及结肠癌中的表达及意义
- Author:
Dehan YUAN
;
Juling KANG
;
Yantao SU
;
Zhixiong WEN
;
Huazhong TANG
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Adenoma;
Immunohistochemistry;
Caspase 3
- From:
Chinese Journal of Postgraduates of Medicine
2012;(32):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of caspase-3 in colon carcinoma,colon adenoma and normal colon mucosa and its clinical significance.Methods The expression of caspase-3 was detected with immunohistochemical EnVision in 60 cases of colon carcinoma,30 cases of colon adenoma and 30 cases of normal colon mucosa.Results The positive expression rates of caspase-3 in colon carcinoma,colon adenoma and normal colorn mucosa were 18.3％(11/60),50.0％(15/30),86.7％(26/30).There was significant difference among three groups(P＜0.01).The expression of caspase-3 was closely related to Dukes clinical stage,differentiation degree,lymph node metastasis and the degree of infiltration(P＜0.01).Conclusion The low expression of caspase-3 may play an important role in the carcinogenesis of colon carcinoma and it is involved in the metastasis and infiltration.
