Analysis of relationship between 1633C/T polymorphism of IL-8 gene and late-onset Alzheimer's disease

VernacularTitle:IL-8基因1633C/T多态性与迟发性阿尔茨海默病关系研究
Author: Feiyan HE ; Mei LIU
Publication Type:Journal Article
Keywords: Alzheimer disease/genetics; Interleukin-8/genetics; Polymorphism,genetic; Genetic predisposition to disease
From: Journal of Chinese Physician 2012;(10):1319-1322
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between interleukin-8 (IL-8) gene 1633C/T polymorphism and late-onset Alzheimer's disease in order to provide genetic reference data for late-onset Alzheimer's disease.Methods Polymorphism distribution of IL-8 gene 1633C/T in 80 LOAD and 80 normal controls were detected by polymerase chain reaction-restriction fragment length polymorphism(PCRRFLP) analysis.The alleles and gene frequencies type were calculated by the direct counting.Type of gene was proceeded with the Hardy-Weinberg balance estimate.The other statistical analyses were carried out with SPSS13.0 software.The genotype frequencies and allele frequencies were compared with the Chisquare test (x2 test).Results For IL-8 gene1633 C/T,the genotype frequencies (CC,20.0％ ; CT,41.2％ ; TT,38.8％) in the LOAD group were not significantly different from those (CC,11.3％ ; CT,40.0％ ; TT,48.7％) in the control group (P ＞ 0.05).Conclusions IL-8 gene 1633 C/T polymorphism is probably not related to the genetic susceptibility of late-onset Alzheimer's disease.