Expression of interleukin-22 and relative CD4+ T cell subsets in ulcerative colitis
10.3760/cma.j.issn.0254-5101.2012.04.007
- VernacularTitle:溃疡性结肠炎患者外周血IL-22及相关CD4+ T细胞亚群的表达
- Author:
Li LI
;
Jiang CAO
;
Ling LIU
;
Zuan ZHU
;
Kejian WU
;
Sujuan FEI
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Interleukin-22;
Th1;
Th17;
Th22
- From:
Chinese Journal of Microbiology and Immunology
2012;32(4):323-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of interlenkin-22 (IL-22) and relative CD4+ T cell subsets in patients with ulcerative colitis (UC),and to explore their roles in the pathogenesis of UC.Methods Thirty-five adult UC patients were enrolled in this study and 35 healthy subjects were taken as control.Plasma IL-22 level was quantified by ELISA.The percentages of Th1,Th17 and Th22 cells in peripheral blood were determined by flow cytometry.The relationships of these results and disease activity were analyzed.Results Plasma IL-22 levels in UC patients [ (354.12±104.22 ) pg/ml ]were significantly higher than that of healthy controls ( P＜0.05 ),and the levels increased significantly in severely active patients.The percentages of Th17 cells in UC patients [ (2.36±0.94) ％ ]were elevated compared to healthy controls ( P＜0.05 ),and the percentages increased significantly in moderately active and severely active patients.The percentages of Th22 cells in UC patients [ (2.27±0.87 ) ％ ]were elevated compared to healthy controls (P±0.05),and the percentages increased significantly in severely active patients.The percentage of Th1 cells was not significantly different between UC patients and normal controls.ConclusionOur resuits demonstrate elevated IL-22 correlated to Th17 and Th22 cells may play an important role in the immunopathogenesis of UC.
