Expression and clinical significance of Rac-1 and HIF-1α in breast cancer
10.3760/cma.j.issn.1006-9801.2012.02.008
- VernacularTitle:乳腺癌组织中Ras相关C3肉毒菌毒物底物1和缺氧诱导因子1α蛋白的表达及其临床意义
- Author:
Yiming BI
;
Yan FU
;
Xiufang CHEN
;
Xinjun LI
;
Yuan CHEN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Ras-related C3 botulinum toxin substrate 1;
Hypoxia-inducible factor-1α;
Immunohistochemistry
- From:
Cancer Research and Clinic
2012;24(2):98-101
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the expression and clinical significance of Ras-related C3 botulinum toxin substrate 1 (Rac-1) protein and hypoxia-inducible factor 1α (HIF-1α) in breast cancer and their relationship with tumor stage, node metastasis status and hormone receptor status. MethodsImmunohistochemical method was used to detect the expression of Rac-1 and HIF-1α protein in 139 specimens of breast cancer,combined with their clinical pathological characteristics and hormone receptor status for statistical analysis.Results The expression of Rac-1 and HIF-1α in breast cancer tissue were 64.75 ％ and 65.47 ％,respectively.The levels were related with the stage of TNM and histological grade (P ＜ 0.05,P ＜ 0.01).There was no significant correlation between these two proteins'expression and the age of patient,primary pathological location, histologic type and menstruation status of breast cancer patients(P ＞ 0.05). The expression of Rac-1 and HIF-1α had no statistical significance between triple negative breast cancer(TNBC)and non-triple negative breast cancer (NTNBC) patients (x2 =1.1229,x2 =0.1786,P ＞ 0.05); The expression level of Rac-1 was positively correlated with HIF-1α in these breast cancer specimens (rs =0.414,P ＜ 0.01).ConclusionThe expression of Rac-1 is positively correlated with HIF-1α level in breast cancer.The relationship between Rac-1 and HIF-1α might be as a new important marker to estimate the invasion,metastasis extent and prognosis in breast cancer.Blocking the regulation between Rac-1 and HIF-1α might be a new treatment target in breast cancer.
