Empiric initial therapy in peritoneal dialysis-related peritonitis
10.3760/cma.j.issn.1001-7097.2011.12.007
- VernacularTitle:腹膜透析相关性腹膜炎经验用药分析
- Author:
Huanqing YAN
;
Yun LI
;
Yongjun BAO
;
Lin TANG
;
Xin HUANG
;
Guoxiu ZHOU
;
Tongying ZHU
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Peritonitis;
Drug resistance;
Antibiotics
- From:
Chinese Journal of Nephrology
2011;27(12):899-902
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathogens,drug resistance and outcomes of continuous ambulatory peritoneal dialysis(CAPD) patients with peritoneal dialysis-related peritonitis in our peritoneal dialysis(PD) centers. Method Data including clinical manifestations,pathogens,treatment,outcome of 93 CAPD cases with peritoneal dialysis-related peritonitis in our peritoneal dialysis(PD) centers were retrospectively analyzed.Results Dialysate culture of 75cases was positive with a positive rate of 80.2％,including 45 cases of gram-positive cocci,21cases of gram-negative bacilli,2 cases of fungi and 5 cases of mixed infection.Coagulase-negative staphylococci were the most common gram-positive cocci.All the gram-positive cocci were sensitive to vancomycin,but the resistance rate to cefazolin was 60.0％ with an increasing tendence year by year.Resistance rate of gram-negative bacilli to ceftazidime was 46.1％.All the gram-negative bacilli were sensitive to imipenem.The withdraw rate of CAPD was 17.2％(16/93) because of peritonitis. Noobviousside-effectofperitonealadministrationofvancomycinwasfound.Conclusions Gram-positive cocci are major pathogens in CAPD-related peritonitis.Now cefasolin is not suitable for the empiric initial treatment.Peritoneal administration of vancomycin should be recommended for peritonitis caused by gram-positive cocci.
