The relationship between carboxylesterase 1 gene polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity
10.3760/cma.j.issn.0578-1426.2012.07.008
- VernacularTitle:羧酸酯酶基因1多态性鉴定及其与抗结核药物肝毒性相关性研究
- Author:
Xueqiong WU
;
Donglin ZHU
;
Junxian ZHANG
;
Yu ZHONG
;
Yun XI
;
Huiru AN
;
Yan LIANG
;
Yourong YANG
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
Hepatotoxicity;
Carboxylesterase 1;
Genetic polymorphism
- From:
Chinese Journal of Internal Medicine
2012;51(7):524-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the genetic polymorphisms of carboxylesterase 1 gene (CESI) and the susceptibility to antituberculosis drug-induced hepatotoxicity (ATBDIH).Methods Genetic polymorphisms of CES1 in 473 tuberculosis patients with or without hepatotoxicity (200∶ 273) after antituberculosis chemotherapy were analyzed by PCR-MassArray.Results In4 tags of CES1 single nucleotide polymorphism (SNP),the frequency of the rs1968753 allele had statistical difference between the hepatotoxicity group and the no-hepatotoxicity group ( P =0.0236 ).The characteristics of anti-hepatotoxicity had been shown relationship with rs8192950 ( P =0.044,OR =0.649,95％ CI =0.426-0.989,AC/AA ) and rs1968753 ( P =0.048,OR =0.556,95％ CI =0.311-0.995,GG/AA).The diplotypes with ‘ CGC' haplotype exhibited significant protection against hepatotoxicity at one copy (P=0.048,OR=0.654,95％CI=0.430-0.996).Conclusions The genetic polymorphisms of CESI might have significant association with ATBDIH.SNP rs8192950 AC genotype and rs1968753 GG genotype might be the candidates for risk prediction of ATBDIH.
