Outcome of postoperative hypopituitarism and hormone replacement situation in 215 patients with pituitary adenoma
10.3760/cma.j.issn.1000-6699.2012.07.006
- VernacularTitle:215例垂体腺瘤术后患者腺垂体功能评估及替代状况分析
- Author:
Meifang ZENG
;
Cuiping JIANG
;
Hongying YE
;
Shuo ZHANG
;
Min HE
;
Yehong YANG
;
Bin LU
;
Renming HU
;
Shiqi LI
;
Yao ZHAO
;
Yongfei WANG
;
Yiming LI
- Publication Type:Journal Article
- Keywords:
Hypopituitarism;
Hormone replacement therapy;
Pituitary neoplasm;
Postoperative period
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(7):546-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the outcome of postoperative hypopituitarism and hormone replacement in patients with pituitary adenoma,and to analyze the potential factors related to postoperative hypopituitarism.Methods A total of 215 postoperative patients with pituitary adenoma were analyzed.Pituitary functions( including gonadal,thyroid,and adrenal axes ) were asessed by strict criteria.Data of surgery history and hormone replacement situation were collected for statistical analysis.Results The prevalence of hypopituitarism was 54.0％,including 36.7％ hypogonadism,32.6％ hypothyroidism,and 28.4％ hypoadrenalism.Replacements of gonadal steroid,glucocorticoid,and thyroxine were carried out in 25.6％,84.3％,and 80.6％ of the cases,respectively.Univariate analysis showed that male sex and large tumor were related to hypopituitarism. Conclusion After pituitary adenomectomy,approximately half of the patients present anterior pituitary dysfunction,while quite a number of them have not been treated appropriately.
