A study of effectiveness and safety of insulin glargine in the treatment of patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1673-4904.2012.16.002
- VernacularTitle:甘精胰岛素控制2型糖尿病患者血糖有效性和安全性研究
- Author:
Qiu CHEN
;
Wenqun HAN
;
Yongbi LIANG
;
Qin ZHANG
;
Yao LI
;
Zhihuang ZUO
;
Lisha SUN
- Publication Type:Journal Article
- Keywords:
Insulin;
Diabete smellitus,type2;
Blood glucose
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(16):4-7
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effectiveness and safety of insulin glargine in the treatment of patients with type 2 diabetes mellitus (T2DM),and verify the new remedy called one central and three steps for T2DM.MethodsUsed multicenter,random,open and self-control study.Two hundred and three cases with T2DM treated with insulin glargine were divided into four groups according to different therapy:30 cases with one needle method,106 cases with one needle and one pill method,48 cases with one long-acting and several short-acting method,and 19 cases with one long-acting,one pill and several short-acting method.The changes of blood glucose,glycosylated hemoglobin (HbA1c),weight and so on before and after treatment were observed.ResultsThe levels of fasting plasma glucose(FPG),2 h postprandial plasma glucose (2hPPG) and HbA1c decreased significantly after treatment than those before treatment[(5.78 ±0.76)mmol/L,(8.37 ±:1.37) mmol/L,(6.81 ±0.38)％ vs. (11.73 ±4.49) mmol/L,(16.73 ±4.96) mmol/L,(9.43 ± 2.31 )％,P ＜ 0.01 ].The weight and body mass index had no obvious changes before and after treatment( P ＞ 0.05 ).There was significant difference in the level of FPG,2hPPG and HbA1c before and after treatment in four groups respectively(P＜0.01 ).There was only 1 case who occurred hypoglycemia during the treatment.ConclusionThe therapy,one central and three steps,is not only effective and safe,but also convenient and cheap for T2DM.
