The roles of catecholamine in cardiac injury after severe acute dichlorvos poisoning
10.3760/cma.j.issn.1671-0282.2012.06.014
- VernacularTitle:儿茶酚胺在重度急性敌敌畏中毒致心脏损伤的作用
- Author:
Xinhua HE
;
Chunsheng LI
;
Junyuan WU
;
Luhui SHEN
- Publication Type:Journal Article
- Keywords:
Dichlorvos poisoning;
Myocardial injury;
Catecholamine;
Atropine;
Pralidoxime chloride;
Cardiac troponin Ⅰ (CTNI);
Acetylcholinesterase (AChE);
Acertylcholine ( Ach )
- From:
Chinese Journal of Emergency Medicine
2012;21(6):617-621
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the role of catecholamine in genesis of myocardium injury after organophosphorus poisoning (OP) in order to elucidate the underlying mechanisms of OP-induced cardiotoxicity.Methods Of 92 patients with severe acute dichlorvos poisoning,41 were consecutively enrolled for study and followed up for three months. The levels of serum creatine kinase isoenzyme myocardium (CK-MB),cardiac troponin Ⅰ (cTnI),acetylcholinesterase (AChE),acetylcholine (Ach),epinephrine and norepinephrine were assayed on the 1st,3rd and 5th days after admission and on the day of discharge.Electrocardiography was recorded every day after admission.ResultsOf them,37 (90.2％ )patients survived and four ( 9.8％ ) patients died during treatment.Sinus tachycardia was found in 37 (90.2％ ) patients and ST-T changes in 33 (80.4％ ) patients.CK-MB and cTnI levels peaked 3 days after admission,and then decreased to normal levels.Serum Ach,epinephrine and norepinephrine peaked on the 1st day after admission and then decreased.ConclusionsSevere acute dichlorvos poisoning is associated with myocardial dysfunction likely caused by increase in catecholamine levels.
