Changes of serum IL-6, IL-10 and IL-1 in patients with Kawasaki disease and its clinical significance
10.3760/cma.j.issn.1008-6706.2012.06.025
- VernacularTitle:川崎病患儿血清白细胞介素-6、-10、-1水平变化及意义
- Author:
Hui Lü
;
Guojun YUN
- Publication Type:Journal Article
- Keywords:
Mucocutaneous lymph node syndrome;
Interleukin-6;
Interleukin-10;
Interleukin-1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(6):850-851
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the serum levels of IL-6,IL-10 and IL-1 in children with Kawasaki disease and its clinical significance.Methods38 childrey with of Kawasaki disease were selected as observction group,then selected 38 cases of normal children as control group.Serum IL-6,IL-10 and IL-1 levels were observed two groups.ResultsObservation group IL-6,IL-10 and IL-1 levels were higher(t =10.3877,15.1010,15.1243,all P＜0.05),acute phase of observation group IL-6,IL-10,IL-1,etc.levels were significantly higher than the sub-acute phase patients ( t =9.7594,11.6486,11.6622,all P ＜ 0.05 ) and control group ( t =11.7032,11.7718,11.8267,all P ＜0.05 ).48h apoptosis rate in the control group( 2.8 ± 0.8 )％ was significantly lower than in children with Kawasaki disease(38.3 ±7.9)％ (t =38.59,P ＜0.01 ).Platelets increased[ (464.0 ± 110.2) × 109/L] of the IL-1 level in children with Kawasaki disease(663 ±94)ng/L was significantly higher than those without elevated platelet [ (307.0 ±104.9) × 109 /L ] of children( 492 ± 92 ) ng/L ( t =13.1044,P ＜ 0.05 ).ConclusionThedetection of serum IL-6,IL-10 and IL-1 levels may aid clinical diagnosis of the condition of children with Kawasaki disease,complications and treatment,have important clinical significance.
