Expression of tumor necrosis factor-α in ovarian carcinoma ascites and its meaning
10.3760/cma.j.issn.1673-4181.2012.01.013
- VernacularTitle:肿瘤坏死因子-α在卵巢肿瘤患者腹水中的表达及意义
- Author:
Yuanyuan CHEN
;
Tianfu YUE
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-α;
Tumor necrosis factor receptor-Ⅰ;
Enzyme linked immunosorbent assay;
Ovarian tumor
- From:
International Journal of Biomedical Engineering
2012;35(1):50-52
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the relationship of ovarian cancer and the ascites levels of TNF-α,and to determine the value of elevated TNF-α ascites level on discriminating the feature of ascites.MethodsAscites levels of TNF-α of 59 specimens of epithelial ovarian tumor,9 specimens of peritoneal primary serous papillary carcinoma (PPSPC) and 6 specimens of endometriosis cyst were detected via ELISA.ResultsAscites levels of TNF-α of patients with EOC,PPSPC,BOT were significantly higher than those with BET and EM,and they were related to the clinical stage,tissue differentiation,lymph node metastasis and volume of ascites.ConclusionAscites levels of TNF-α have the high sensitivity and specificity for diagnosis of ovarian cancer.It might be the tumor marker of ovarian cancer.
